Active Comparator
Apixaban for at least 10 days
For at least 10 days post-surgery and until venography is performed, starting within 12 to 24 hours after TKA surgery
Drug :
Apixaban
twice daily oral administration
Experimental
BAY1213790 pre and post surgery
Post-surgery administration part (A): Single infusion in the morning following the day of Total Knee Arthroplasty (TKA) Pre-surgery administration part (B): Single infusion in the second half of the day before Total Knee Arthroplasty (TKA)
Drug :
BAY1213790
single dose intravenous infusion
Active Comparator
Enoxaparin for at least 10 days
Started either in the evening before TKA or 6-8 hours after TKA (at investigator's discretion), followed by once daily subcutaneous injections for at least 10 days and until venography is performed
Drug :
Enoxaparin
daily subcutaneous injection
|