| Detailed Description |
Healthcare-associated infections (HAIs), particularly those due to multidrug-resistant
organisms (MDROs), are of great clinical and public health concern. Although evidence-based
prevention strategies have resulted in some success in curtailing HAIs, novel approaches are
needed to achieve further reductions. Efforts to curb the emergence of MDROs have been
largely unsuccessful. Thus, new strategies to address MDROs are urgently needed. This grant
is comprised of two complementary studies that focus on identifying innovative approaches to
more effectively prevent HAIs and curtail further emergence of MDROs.
We will conduct a randomized controlled trial (RCT) to assess the efficacy of copper
oxide-impregnated textiles in preventing HAIs and MDROs as well as in reducing environmental
microbial contamination. We hope to provide critical information to inform the development of
novel strategies, and enhance the impact of existing strategies, to successfully address HAIs
and MDROs.
For approximately four months the hospital is conducting a research study to learn about the
possible impact of copper linens in reducing hospital acquired infections. Some rooms will
have copper linens (Group 1) and some rooms will have regular linens (Group 2). The linens
will be comprised of the top and bottom sheets, pillowcase cover, and hospital gown.
Patients in both groups will be asked to provide samples during their stay in the ICU. For
both study groups, the linens will be sampled twice after they are placed. This will occur on
2 consecutive days. At the same time, study staff will take samples from several areas of the
room (the hand rails, overbed table, nurse call button).
Patients will also be asked to allow the research team to obtain swabs of the nose,
per-rectal area, armpit and groin. These swabs will be performed on their first day enrolled
into the study, then 4 days later, and every week until ICU discharge.
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| Study Groups/Cohorts |
Copper linen exposure
Subjects will use copper linens during their hospital stay, consisting of copper hospital gowns, copper bed sheets (top and bottom sheets), and copper pillow covers.
A subset of 50 subjects from this arm will be recruited to provide three types of swabs to calculate the microbial burden on copper linens. Linen swabs, anatomical swabs and environmental swabs will be collected from subjects and subject hospital rooms will be collected to do bacteria counts.
Non-copper linen exposure
Subjects will not have exposure to copper linens during their hospital stay. They will use the usual hospital linens provided by hospital, not containing copper.
A subset of 50 subjects from this arm will be recruited to provide three types of swabs to calculate the microbial burden on copper linens. Linen swabs, anatomical swabs and environmental swabs will be collected from subjects and subject hospital rooms will be collected to do bacteria counts.
|
| Study Arms |
Experimental
Copper linen exposure
Subjects will use copper linens during their hospital stay, consisting of copper hospital gowns, copper bed sheets (top and bottom sheets), and copper pillow covers.
A subset of 50 subjects from this arm will be recruited to provide three types of swabs to calculate the microbial burden on copper linens. Linen swabs, anatomical swabs and environmental swabs will be collected from subjects and subject hospital rooms will be collected to do bacteria counts.
Other :
Copper linen exposure
Subjects will use hospital linens (top sheet, bottom sheet, pillow case, gown) made with copper to see if this helps reduce infections during their hospital stay.
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