Active Comparator
Dronabinol
A direct comparison of cannabis and dronabinol has not been performed in a clinical population. The present study will fill this void by performing a randomized, controlled 8 week trial comparing the effectiveness of oral versus vaporized cannabis in patients with neuropathic low back pain.
Drug :
dronabinol
Administration of vaporized cannabis plus either dronabinol or placebo pill
Placebo Comparator
Placebos
The present study is designed to evaluate whether or not a medium dose of cannabis (3.7% delta-9-THC/5.6% CBD) can maintain an analgesic response over an eight week period compared to placebo.
Drug :
Placebos
Administration of vaporized cannabis plus either dronabinol or placebo pill
Experimental
Vaporized Cannabis 3.7% THC/5.6% CBD
The eight week outpatient study will compare the efficacy and side effect profile of cannabis (3.7%THC/5.6%CBD) and dronabinol. We will also perform a human laboratory experiment evaluating driving using the same study medications that subjects received during their 8 week outpatient treatment.
Drug :
Vaporized Cannabis 3.7% THC/5.6% CBD
Administration of vaporized cannabis plus either dronabinol or placebo pill
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