The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine

ID: NCT02212990
Status: Completed
Phase: N/A
Start Date: September 01, 2014
First Submitted: August 07, 2014
Last Updated: February 05, 2018
Results: N/A
Organization: Duke University
Sponsors & Collaborators: Duke University, Centers for Disease Control and Prevention
Location: United States
Conditions: Fever
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Study Description

Brief Summary

This study aims to conduct a double-blind, placebo-controlled study to assess the effect of prophylactic antipyretics on the immune responses and rates of fever after inactivated influenza vaccine (IIV) in children 6 through 47 months of age.

In this study, 160 healthy children, 6 through 47 months of age, including some children at risk of febrile seizure, will be randomized to one of three different treatment arms. Children will receive either blinded therapy with prophylactic acetaminophen or placebo immediately following and every 4 to 6 hours in the 24 hours after receipt of a dose of IIV or open-label ibuprofen every 6 to 8 hours in the 24 hours after receipt of a dose of IIV. Children will be followed for the occurrence of fever, fussiness, changes in appetite and sleep patterns, and use of medical services on the day of and for two days following vaccination. Antibody to influenza antigens contained in the respective 2014-2015 and 2015-2016 vaccines as measured by hemagglutination inhibition (HAI) antibody will be assessed at baseline and four weeks following vaccination. The proportions of children experiencing fever, having solicited side effects, using medical services, demonstrating a serologic response corresponding to seroprotection and seroconversion to each of the IIV antigens will be determined for groups of children in each of the three treatment arms. Likewise geometric mean HAI titers (GMTs) and corresponding 95% confidence intervals for each IIV antigen will be calculated for the three treatment arms. The investigators hope to learn whether or not prophylactic antipyretics affect the immune response and fever rates following IIV.

Detailed Description

Condition or disease Intervention/treatment Phase

Fever

Other: Acetaminophen Arm
Other Names
Other: Placebo Arm
Other Names
Other: Ibuprofen Arm
Other Names
N/A

Tracking Information

First Submitted DateAugust 07, 2014
Last Update Posted DateFebruary 05, 2018
Start DateSeptember 01, 2014
Actual Completion DateMarch 01, 2016
Primary Completion DateMarch 01, 2016
Results First Submitted DateN/A
Received Results Disposit DateN/A

Current Primary Outcome Measures

  • Seroconversion [Time Frame: One month following the last dose of IIV]

    Seroconversion (an HAI titer ≥ 1:40 four weeks post- vaccination if the baseline titer is < 1:10 or a four-fold rise in HAI titer if the baseline titer is ≥ 1:10) for each IIV antigen

Original Primary Outcome Measures

Not Available

Current Secondary Outcome Measures

  • Seroprotection [Time Frame: One month following the last dose of IIV]

    Seroprotection (the proportion of subjects with an HAI titer >1:40) to each IIV antigen

  • Geometric mean HAI titer [Time Frame: One month following the last dose of IIV]

    Geometric mean HAI titer (GMT) and 95% confidence interval for each IIV antigen

Original Secondary Outcome Measures

Not Available

Study Design

Brief TitleThe Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine
Official TitleClinical Immunization Safety Assessment (CISA): A Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine (IIV) Administered to Children 6 Through 47 Months of Age
Brief Summary

This study aims to conduct a double-blind, placebo-controlled study to assess the effect of prophylactic antipyretics on the immune responses and rates of fever after inactivated influenza vaccine (IIV) in children 6 through 47 months of age.

In this study, 160 healthy children, 6 through 47 months of age, including some children at risk of febrile seizure, will be randomized to one of three different treatment arms. Children will receive either blinded therapy with prophylactic acetaminophen or placebo immediately following and every 4 to 6 hours in the 24 hours after receipt of a dose of IIV or open-label ibuprofen every 6 to 8 hours in the 24 hours after receipt of a dose of IIV. Children will be followed for the occurrence of fever, fussiness, changes in appetite and sleep patterns, and use of medical services on the day of and for two days following vaccination. Antibody to influenza antigens contained in the respective 2014-2015 and 2015-2016 vaccines as measured by hemagglutination inhibition (HAI) antibody will be assessed at baseline and four weeks following vaccination. The proportions of children experiencing fever, having solicited side effects, using medical services, demonstrating a serologic response corresponding to seroprotection and seroconversion to each of the IIV antigens will be determined for groups of children in each of the three treatment arms. Likewise geometric mean HAI titers (GMTs) and corresponding 95% confidence intervals for each IIV antigen will be calculated for the three treatment arms. The investigators hope to learn whether or not prophylactic antipyretics affect the immune response and fever rates following IIV.

Detailed Description

Study TypeInterventional
Study PhaseN/A
Estimated Enrollment
104
Allocation
Randomized
Interventional Model
Parallel Assignment
Masking
Quadruple
Primary Purpose
Prevention
Conditions
Fever
Target Follow-Up Duration N/A
Biospecimen:
N/A
Sampling MethodN/A
Study PopulationN/A
Intervention
Other: Acetaminophen Arm

Blinded Therapy

Other Names
Other: Placebo Arm

Blinded Therapy

Other Names
Other: Ibuprofen Arm

Open Label Therapy

Other Names
Study Groups/Cohorts
Acetaminophen Arm
Acetaminophen Suspension 160mg / 5mL Oral dose immediately following IIV and every 4 to 6 hours up to 24 hours (Maximum 5 oral doses)

Placebo Arm
Placebo Suspension Oral dose immediately following IIV and every 4 to 6 hours up to 24 hours (Maximum 5 oral doses)

Ibuprofen Arm
Ibuprofen Suspension 100mg / 5mL Oral dose immediately following IIV and every 6 to 8 hours up to 24 hours (Maximum 4 oral doses)

Study Arms
Active Comparator Acetaminophen Arm
Acetaminophen Suspension 160mg / 5mL Oral dose immediately following IIV and every 4 to 6 hours up to 24 hours (Maximum 5 oral doses)
Other : Acetaminophen Arm
Blinded Therapy

Active Comparator Ibuprofen Arm
Ibuprofen Suspension 100mg / 5mL Oral dose immediately following IIV and every 6 to 8 hours up to 24 hours (Maximum 4 oral doses)
Other : Ibuprofen Arm
Open Label Therapy

Placebo Comparator Placebo Arm
Placebo Suspension Oral dose immediately following IIV and every 4 to 6 hours up to 24 hours (Maximum 5 oral doses)
Other : Placebo Arm
Blinded Therapy

Arm Intervention/Treatment
Active Comparator Acetaminophen Arm
Acetaminophen Suspension 160mg / 5mL Oral dose immediately following IIV and every 4 to 6 hours up to 24 hours (Maximum 5 oral doses)
Other : Acetaminophen Arm
Active Comparator Ibuprofen Arm
Ibuprofen Suspension 100mg / 5mL Oral dose immediately following IIV and every 6 to 8 hours up to 24 hours (Maximum 4 oral doses)
Other : Ibuprofen Arm
Placebo Comparator Placebo Arm
Placebo Suspension Oral dose immediately following IIV and every 4 to 6 hours up to 24 hours (Maximum 5 oral doses)
Other : Placebo Arm

Recruitment Information

Recruitment Status:Completed
Enrollment104
Completion DateMarch 01, 2016
Eligibility Criteria: Inclusion Criteria:
1. The child must be 6 through 47 months of age.
2. The child must weigh 5.4 kilograms.
3. The child must be receiving IIV this season.
4. If the child is two years of age or older and needs two doses of influenza vaccine this season the parent/guardian intends for the child to receive IIV for the second dose.
5. The parent/guardian must be willing and capable of providing written informed consent for the child.
6. The parent/guardian must be available for follow-up and must at minimum have telephone access.
7. The parent/guardian must agree to sign a medical release for the child so that study personnel may obtain medical information about the child's health (if needed).

Exclusion Criteria:
1. History of receipt of current year's licensed influenza vaccine.
2. Planned receipt of the live attenuated nasally administered influenza vaccine this year
3. History of a severe allergic reaction (e.g. anaphylaxis) to any component of influenza vaccine, including egg protein, formaldehyde, octylphenol ethoxylate, gelatin, or thimerosal if using thimerosal containing vaccine.
4. History of a severe allergic reaction (e.g. anaphylaxis) following a prior dose of influenza vaccine.
5. History of an allergic reaction following acetaminophen or ingredients in the acetaminophen product.
6. History of an allergic reaction following ibuprofen or ingredients in the ibuprofen product.
7. History of an allergic reaction following aspirin or other pain reliever or fever reducer.
8. History of liver disease.
9. Currently taking the blood thinning drug warfarin (Coumadin) or other blood thinners.
10. History of recent or planned heart surgery within the past 3 months or next 3 months.
11. History of stomach ulcer or bleeding problem.
12. Currently already routinely taking prescription or nonprescription non-steroidal anti-inflammatory drugs or NSAIDs (aspirin, ibuprofen, naproxen, or others)
13. Received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to vaccination in this study or expects to receive a licensed vaccine during the 28 days following the last influenza vaccination in this study. Concomitant vaccinations are not allowed.
14. Routine immunizations are delayed or will be delayed by not being able to receive a concomitantly administered vaccine or a needed vaccine in the 28 days following the last influenza vaccination in this study.
15. Received an experimental/investigational agent (vaccine, drug, biologic, device, blood product, or medication) within 28 days prior to vaccination in this study, or expects to receive an experimental/investigational agent within the follow-up time period (28 days after the last vaccination in this study).
16. A moderate to severe acute illness and/or a reported temperature greater than or equal to 100.0°F (37.8°C) within 72 hours prior to first dose of IIV or an axillary temperature greater than or equal to 100.0°F (37.8°C) at the time of enrollment. (This may result in a temporary delay of vaccination. For those needing a second dose of IIV, a moderate to severe acute illness and/or a reported temperature greater than or equal to 100.0°F (37.8°C) within 72 hours prior to second dose of IIV may result in a temporary delay of vaccination).
17. Receipt of an antipyretic medication (acetaminophen or ibuprofen) within 72 hours prior to the first dose of IIV (This may result in a temporary delay of vaccination) or is already planning to administer a prophylactic antipyretic medication on the day of and the day following any dose of IIV (this exclusion does not apply if the caretaker indicates he/she might administer antipyretics after vaccination to reduce a fever).
18. Immunosuppression as a result of an underlying illness or treatment, or use of anti-cancer chemotherapy or radiation therapy within the preceding 36 months.
19. Long term (at least 14 days of prednisone 2 mg/kg/day or equivalent other glucocorticoid), any parenteral steroids, high-dose inhaled steroids (>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding 6 months (topical and nasal steroids are allowed).
20. History of Guillain-Barré syndrome within 6 weeks of a prior dose of influenza vaccine.
21. Has any condition that would, in the opinion of the site investigator, place the participant at an unacceptable risk of injury or render the participant unable to meet the requirements of the protocol.
GenderAll
Age6 Months to 47 Months
Accepts Healthy VolunteersAccepts Healthy Volunteers
Contacts
Not Available
Listed Location Countries
United States

Administrative Information

NCT Number:NCT02212990
Other Study ID Numbers
Pro00056213
200-2012-53663
Has Data Monitoring CommitteeNo
U.S. FDA-regulated Product Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Device Product Not Approved or Cleared by U.S. FDA: No
IPD Sharing Statement
Not Available
Responsible Party,
Study Sponsor
Duke University
Collaborators
Centers for Disease Control and Prevention
Investigators
Principal Investigator
Emmanuel B Walter, MD, MPH
Duke Unviersity School of Medicine
Principal Investigator
Karen Broder, MD
Centers for Diseaes Control and Prevention