Main Inclusion Criteria:|
- Infection caused by Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus
faecalis, or Enterococcus faecium that requires inpatient hospitalization and
treatment with injectable antibiotics**
- Site of infection: complicated skin and skin structure infection; urinary tract
infection; intra-abdominal infection; infective endocarditis; or bloodstream infection
- Pathogen resistant to, or patient intolerant of: beta-lactams, vancomycin,
quinupristin/dalfopristin, or linezolid.
- Unable to receive any other standard commercially available antibacterial therapy for
- Creatinine clearance less than 40 mL/min**
- Hemodialysis or peritoneal dialysis
- Admitted to the hospital for drug overdose or other conditions associated with
rhabdomyolysis, or is expected to require repeated intramuscular injections
- Creatine phosphokinase (CPK) level greater than 2.5 times above the upper limit of
normal (ULN) at screening; if the elevation in CPK can be attributed to an obvious
cause (eg, surgery)**
- Central nervous system infection
- Pulmonary infection.
(**) An exemption may be granted for patients not satisfying these criteria following a
conversation with the Medical Monitor.